Developing novel non-hydroxamate histone deacetylaseinhibitors: the chelidamic warhead
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چکیده
منابع مشابه
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.
The antimalarial activity and pharmacology of a series of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors (HDACIs) was evaluated. In in vitro growth inhibition assays approximately 50 analogs were evaluated against four drug resistant strains of Plasmodium falciparum. The range of 50% inhibitory concentrations (IC(50)s) was 0.0005 to >1 microM. Five analogs exhibited IC...
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ژورنال
عنوان ژورنال: MedChemComm
سال: 2012
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c1md00249j